In this service project, we will prepare chemically defined oligomers of chitin. Using automated glycan assembly (AGA) we can obtained oligomers with full control over the sequence, length, degree and pattern of acetylation. Representative structures can be found in the references below. Each oligomer is provided on a mg scale (1-5 μmols), for interest in bigger quantities please contact the responsible person. Upon request, the oligomer can be prepared with an amino-linker at the reducing end for further conjugation. Additional modifications can be discussed upon request.

References:

Tyrikos-Ergas, T.; Bordoni, V.; Fittolani, G.; Chaube, M.; Grafmüller, A.; Seeberger, P. H.; Delbianco, M.: Systematic structural characterization of chitooligosaccharides enabled by Automated Glycan Assembly. Chemistry – A European Journal 27 (7), pp. 2321 – 2325 (2021)

Fittolani, G.; Tyrikos-Ergas, T.; Vargová, D.; Chaube, M.; Delbianco, M.: Progress and challenges in the synthesis of sequence controlled polysaccharides. Beilstein Journal of Organic Chemistry 17, pp. 1981 – 2025 (2021)

Huang, J.-Y.; Delbianco, M.: Recent developments in solid-phase glycan synthesis. Synthesis (2022), DOI: 10.1055/a-1938-2293