We are excited to announce Dr. Kelvin Anggara’s recent publication in Science, representing a significant breakthrough in glycoconjugate analysis. Dr. Anggara’s work introduces a novel approach utilizing low-temperature scanning tunneling microscopy for single-molecule analysis of glycoconjugates. This technique enables the direct imaging of individual glycoconjugate molecules, revealing detailed structures and attachment sites of glycans in various biomolecules, including glycopeptides, glycolipids, and glycoproteins.
The ability of this innovative imaging technique to provide valuable insights into the configurations and interactions of glycans within biomolecules will help advance our understanding of biological processes and overcome challenges associated with studying complex sugar chains attached to proteins and lipids.
Congratulations to Dr. Anggara and his team on this remarkable achievement.
Citation: Kelvin Anggara et al., Direct observation of glycans bonded to proteins and lipids at the single-molecule level. Science 382, 219-223 (2023).