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Prof. Alexander Weber, Ph.D.
Telephone: +49 7071 29 87623
Fax:
E-mail: alexander.weber@uni-tuebingen.de
Eberhard Karls University Tübingen
Interfaculty Institute of Cell Biology
Department of Immunology
Auf der Morgenstelle 15, 72076 Tübingen
https://www.immunology-tuebingen.de/groups/alexander-nr-weber.html
CV
Academic Education
| Year | |
| 1996-2000 | Studies of Biochemistry at the University Tübingen and University of Cambridge, UK (scholarships by ‘Studienstiftung des Deutschen Volkes’ and ‘Evangelisches Studienwerk’) |
| 2000 | Master of Philosophy Biochemistry at the University of Cambridge, UK |
| 2000-2004 | Doctor of Philosophy (PhD) Biochemistry, University of Cambridge, UK and GlaxoSmithKline Medicines Research Centre, Stevenage, UK. Title: Structure-function relationships of human and Drosophila Toll-like receptors. Supervisor Prof. Dr. Nicholas J. Gay |
Academic Career
| Year | |
| 2004-2005 | Scientific manager, Cambridge University Baculovirus Protein Expression Facility (funded by the Wellcome Trust UK) |
| 2004-2005 | Postdoctoral fellow, Toll receptor group (Prof. Nicholas Gay), Department of Biochemistry, University of Cambridge, UK |
| 2006 | Junior Group Leader (Emmy Noether until 2013), German Cancer Research Center (DKFZ), Heidelberg, Research focus: Toll-like receptor signalling and genetic variants |
| 2007-2011 | Junior Group Leader (Emmy Noether until 2013), German Cancer Research Center (DKFZ), Heidelberg, Research focus: Toll-like receptor signalling and genetic variants |
| 2011-2017 | W1-Junior Professor of Innate Immunity, Interfaculty Institute of Cell Biology, Department of Immunology, Tübingen University. Research focus: Pathogen recognition receptor signalling and genetic variants |
| 2016 | Offer of appointment as Chair of Cancer Biology, Lancaster University, UK (declined) |
| 2017 | W3-Professor of Innate Immunity, Interfaculty Institute of Cell Biology, Department of Immunology, Section Innate Immunity, Tübingen University. Research focus: Pathogen recognition receptor signalling and genetic variants |
| 2017 | Acting/deputy head/director, Interfaculty Institute of Cell Biology, Tübingen University |
Research Areas
- The focus of our laboratory is the study of pattern recognition receptors (PRRs), a group of host sensor molecules critical for detecting exogenous and endogenous threats. We hope to provide important insights into PRR signaling pathways both on the molecular level as well as their role in complex disease settings such as infections, sterile inflammation and cancer. A specific emphasis is the recognition of so-called microbe-associated molecular patterns (MAMPs), where we would like to understand the molecular basis for immunogenicity and its regulation. This is also with a view to identify novel points of therapeutic intervention, either augmenting or dampening PRR signals depending on the pathophysiological context. Recently, we have turned our attention to the sensing of chito-oligomers by Toll-like receptors (TLRs), the most prominent group of PRRs, hoping to gain valuable insights into their contribution to fungal infection as well as allergic asthma.
